Closerin
Closerin Brand names, Closerin Analogs
- Cicloserina
- Closerin
- Closina
- Cyclomycin
- Cyclorin
- Cycloserin
- Cycloserine, D-
- D-CS
- D-Cycloserine
- D-Cycloserine synth. BP 88
- D-Cycloserine, synthetic
- D-Oxamicina
- D-Oxamycin
- DL-Cycloserine
- Farmiserina
- Farmiserine
- L-Cycloserine
- Micoserina
- Miroserina
- Miroseryn
- Novoserin
- Orientomycin
- Oxamicina
- Oxamycin
- Oxymycin
- Seromycin
- Tebemicina
- Tisomycin
- Wasserina
- alpha-Cycloserine
Closerin Brand Names Mixture
- No information avaliable
Closerin Chemical_Formula
C3H6N2O2
Closerin RX_link
No information avaliable
Closerin fda sheet
Closerin msds (material safety sheet)
Closerin Synthesis Reference
No information avaliable
Closerin Molecular Weight
102.092 g/mol
Closerin Melting Point
147 oC
Closerin H2O Solubility
Soluble
Closerin State
Solid
Closerin LogP
-1.631
Closerin Dosage Forms
Capsules (red and gray capsules, oral, 250mg)
Closerin Indication
Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Closerin Pharmacology
Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria
Closerin Absorption
Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Closerin side effects and Toxicity
Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Closerin Patient Information
Closerin Organisms Affected
Enteric bacteria and other eubacteria
