Clobetasole propionate
Clobetasole propionate Brand names, Clobetasole propionate Analogs
Clobetasole propionate Brand Names Mixture
- No information avaliable
Clobetasole propionate Chemical_Formula
C25H32ClFO5
Clobetasole propionate RX_link
http://www.rxlist.com/cgi/generic/olux.htm
Clobetasole propionate fda sheet
Clobetasole propionate msds (material safety sheet)
Clobetasole propionate Synthesis Reference
No information avaliable
Clobetasole propionate Molecular Weight
466.97 g/mol
Clobetasole propionate Melting Point
195.5-197 oC
Clobetasole propionate H2O Solubility
3.86 mg/L
Clobetasole propionate State
Solid
Clobetasole propionate LogP
3.588
Clobetasole propionate Dosage Forms
Foam (0.05%) and ointment (usp 0.05%, supplied in 15 g, 30 g, and 45 g tubes)
Clobetasole propionate Indication
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Clobetasole propionate Pharmacology
Like other topical corticosteroids, clobetasol has anti-inflammatory, antipruritic, and vasoconstrictive properties. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.
Clobetasole propionate Absorption
Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
Clobetasole propionate side effects and Toxicity
Oral LD50 in rat and mouse is >3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
Clobetasole propionate Patient Information
Clobetasole propionate Organisms Affected
Humans and other mammals
