Clavulanate
Clavulanate Brand names, Clavulanate Analogs
Clavulanate Brand Names Mixture
- Amoksiklav (potassium clavulanate + amoxicillin)
- Augmentin (potassium clavulanate + amoxicillin)
- Ciblor (potassium clavulanate + amoxicillin)
- Klavocin (potassium clavulanate + amoxicillin)
- Neo-Duplamox (potassium clavulanate + amoxicillin)
Clavulanate Chemical_Formula
C8H9NO5
Clavulanate RX_link
No information avaliable
Clavulanate fda sheet
Clavulanate msds (material safety sheet)
Clavulanate Synthesis Reference
M. Cole et al.; Ger. Pat. 2,517,316(1975)
Clavulanate Molecular Weight
199.161 g/mol
Clavulanate Melting Point
117.5-118 oC
Clavulanate H2O Solubility
300 mg/mL (potassium salt)
Clavulanate State
Solid
Clavulanate LogP
-0.919
Clavulanate Dosage Forms
Tablet; Tablet (extended-release); Suspension
Clavulanate Indication
For use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with Staph. aureus and Bacteroides fragilis, or with beta-lactamase producing H. influenzae and E. coli.
Clavulanate Pharmacology
Clavulanic acid, produced by the fermentation of Streptomyces Clavuligerus, is a beta-lactam structurally related to the penicillins. Clavulanic acid is used in conjunction with amoxicillin for the treatment of bronchitis and urinary tract, skin, and soft tissue infections caused by beta-lactamase producing organisms.
Clavulanate Absorption
75%
Clavulanate side effects and Toxicity
Gastrointestinal symptoms including stomach and abdominal pain, vomiting, and diarrhea. Rash, hyperactivity, or drowsiness have also been observed in a small number of patients
Clavulanate Patient Information
Patients should be counselled that antibacterial drugs, including AUGMENTIN XR,
should only be used to treat bacterial infections. They do not treat viral
infections (e.g., the common cold). When AUGMENTIN XR is prescribed to treat a
bacterial infection, patients should be told that although it is common to feel
better early in the course of therapy, the medication should be taken exactly
as directed. Skipping doses or not completing the full course of therapy may decrease
the effectiveness of the immediate treatment, and (2) increase the likelihood that
bacteria will develop resistance and will not be treatable by AUGMENTIN XR or other
antibacterial drugs in the future. Discard any unused medicine.
should only be used to treat bacterial infections. They do not treat viral
infections (e.g., the common cold). When AUGMENTIN XR is prescribed to treat a
bacterial infection, patients should be told that although it is common to feel
better early in the course of therapy, the medication should be taken exactly
as directed. Skipping doses or not completing the full course of therapy may decrease
the effectiveness of the immediate treatment, and (2) increase the likelihood that
bacteria will develop resistance and will not be treatable by AUGMENTIN XR or other
antibacterial drugs in the future. Discard any unused medicine.
Clavulanate Organisms Affected
Enteric bacteria and other eubacteria
