Cholestat
Cholestat Brand names, Cholestat Analogs
Cholestat Brand Names Mixture
- No information avaliable
Cholestat Chemical_Formula
C25H38O5
Cholestat RX_link
http://www.rxlist.com/cgi/generic/simva.htm
Cholestat fda sheet
Cholestat msds (material safety sheet)
Cholestat Synthesis Reference
W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)
Cholestat Molecular Weight
418.566 g/mol
Cholestat Melting Point
135-138oC
Cholestat H2O Solubility
0.76 mg/L
Cholestat State
Solid
Cholestat LogP
4.937
Cholestat Dosage Forms
Tablet (oral)
Cholestat Indication
For the treatment of hypercholesterolemia.
Cholestat Pharmacology
Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.
Cholestat Absorption
Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.
Cholestat side effects and Toxicity
No information avaliable
Cholestat Patient Information
Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.
Cholestat Organisms Affected
Humans and other mammals
