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Cholestat
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Cholestat Brand names, Cholestat Analogs

Cholestat Brand Names Mixture

  • No information avaliable

Cholestat Chemical_Formula

C25H38O5

Cholestat RX_link

http://www.rxlist.com/cgi/generic/simva.htm

Cholestat fda sheet

Cholestat FDA

Cholestat msds (material safety sheet)

Cholestat Synthesis Reference

W. F. Hoffman et al., U.S. Pat. 4,444,784 (1984)

Cholestat Molecular Weight

418.566 g/mol

Cholestat Melting Point

135-138oC

Cholestat H2O Solubility

0.76 mg/L

Cholestat State

Solid

Cholestat LogP

4.937

Cholestat Dosage Forms

Tablet (oral)

Cholestat Indication

For the treatment of hypercholesterolemia.

Cholestat Pharmacology

Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B.

Cholestat Absorption

Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues.

Cholestat side effects and Toxicity

No information avaliable

Cholestat Patient Information

Patients should be advised about substances they should not take concomitantly with simvastatin and be advised to report promptly unexplained muscle pain, tenderness, or weakness. Patients should also be advised to inform other physicians prescribing a new medication that they are taking ZOCOR.

Cholestat Organisms Affected

Humans and other mammals