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Chemet Brand names, Chemet Analogs

Chemet Brand Names Mixture

  • Didrocal (Calcium Carbonate + Etidronate Disodium)

Chemet Chemical_Formula


Chemet RX_link

Chemet fda sheet

Chemet FDA

Chemet msds (material safety sheet)

Chemet MSDS

Chemet Synthesis Reference

No information avaliable

Chemet Molecular Weight

287.213 g/mol

Chemet Melting Point


Chemet H2O Solubility

13.4 mg/mL in distilled water at 25°C (disoproxil fumarate salt)

Chemet State


Chemet LogP


Chemet Dosage Forms

Tablets for oral administration (300 mg)

Chemet Indication

For use, in combination with other antiretroviral agents, for the treatment of HIV-1 infection.

Chemet Pharmacology

Tenofovir belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. Tenofovir is currently in late-stage clinical trials for the treatment of hepatitis B. Tenofovir disoproxil fumarate is an acyclic nucleoside phosphonate diester analog of adenosine monophosphate. Tenofovir requires initial diester hydrolysis for conversion to tenofovir and subsequent phosphorylations by cellular enzymes to form tenofovir diphosphate. Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.

Chemet Absorption

The oral bioavailability in fasted patients is approximately 25%. Administration of food (high fat meal containing 40 to 50% fat) increases the oral bioavailability, with an increase in the AUC of approximately 40%.

Chemet side effects and Toxicity

Limited clinical experience at doses higher than the therapeutic dose of tenofovir 300 mg is available. In Study 901 tenofovir disoproxil fumarate 600 mg was administered to 8 patients orally for 28 days. No severe adverse reactions were reported. The effects of higher doses are not known.

Chemet Patient Information

Chemet Organisms Affected

Human immunodeficiency virus