Ceredase (Genzyme)

• Enzyme replacement
• ATC:A16AB02

• Acid beta-glucosidase
• Alglucerase
• Beta-glucocerebrosidase
• D-glucosyl-N-acylsphingosine glucohydrolase
• Glucosylceramidase precursor
• Ceredase (Genzyme)
• Cerezyme (Genzyme Corp)

• No information avaliable

C₂₅₃₂H₃₈₅₄N₆₇₂O₇₁₁S₁₆

http://www.rxlist.com/cgi/generic2/imiglucerase.htm

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55597.4

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Liquid

-0.168

Powder for solution; Solution (IV injection)

For the treatment of Gaucher's disease (deficiency in glucocerebrosidase)

Gaucher disease is characterized by a functional deficiency in Beta-glucocerebrosidase enzymatic activity and the resultant accumulation of lipid glucocerebroside in tissue macrophages which become engorged and are termed Gaucher cells. Gaucher cells are typically found in liver, spleen and bone marrow. This can lead to an enlarged spleen and liver (hepatosplenomegaly). Secondary hematologic sequelae include severe anemia and thrombocytopenia. Injections of imiglucerase into Gaucher disease patients leads to elevated serum levels of the enzyme and reduction in the accumulation of glucocerebroside leading to reduced anemia and thrombocytopenia, reduced spleen and liver size, and decreased cachexia

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Humans and other mammals