Cephotaxime
Cephotaxime Brand names, Cephotaxime Analogs
Cephotaxime Brand Names Mixture
- No information avaliable
Cephotaxime Chemical_Formula
C16H17N5O7S2
Cephotaxime RX_link
http://www.rxlist.com/cgi/generic/cefotax.htm
Cephotaxime fda sheet
Cephotaxime msds (material safety sheet)
Cephotaxime Synthesis Reference
No information avaliable
Cephotaxime Molecular Weight
455.468 g/mol
Cephotaxime Melting Point
No information avaliable
Cephotaxime H2O Solubility
Soluble
Cephotaxime State
Solid
Cephotaxime LogP
-0.685
Cephotaxime Dosage Forms
Injection and infusion
Cephotaxime Indication
Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
Cephotaxime Pharmacology
Cefotaxime is a third generation intravenous cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotaxime works by inhibiting bacterial cell wall biosynthesis. A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives.
Cephotaxime Absorption
Rapidly absorbed following intramuscular injection.
Cephotaxime side effects and Toxicity
Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Oral rat LD50 is over 20,000 mg/kg while intravenous rat LD50 is over 7,000 mg/kg.
Cephotaxime Patient Information
No information avaliable
Cephotaxime Organisms Affected
Enteric bacteria and other eubacteria
