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Cefzon (TN) Brand names, Cefzon (TN) Analogs

Cefzon (TN) Brand Names Mixture

  • No information avaliable

Cefzon (TN) Chemical_Formula

C14H13N5O5S2

Cefzon (TN) RX_link

http://www.rxlist.com/cgi/generic2/cefdin.htm

Cefzon (TN) fda sheet

Cefzon_(TN) FDA

Cefzon (TN) msds (material safety sheet)

Cefzon_(TN) MSDS

Cefzon (TN) Synthesis Reference

No information avaliable

Cefzon (TN) Molecular Weight

395.416 g/mol

Cefzon (TN) Melting Point

No information avaliable

Cefzon (TN) H2O Solubility

No information avaliable

Cefzon (TN) State

Solid

Cefzon (TN) LogP

0.657

Cefzon (TN) Dosage Forms

Capsules for oral administration (300mg); Oral suspension (125mg per 5mL solution)

Cefzon (TN) Indication

For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by H. influenzae (including b-lactamase producing strains), H. parainfluenzae (including b-lactamase producing strains), S. pneumoniae (penicillin-susceptible strains), S. pyogenes, S. aureus (including b-lactamase producing strains), and M. catarrhalis.

Cefzon (TN) Pharmacology

Cefdinir is a third generation cephalosporin with a broad spectrum of activity against enteric gram-negative rods. Cefdinir is stable in the presence of some, but not all, b-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.

Cefzon (TN) Absorption

Maximal plasma cefdinir concentrations occur 2 to 4 hours postdose following capsule or suspension administration. Estimated bioavailability of cefdinir capsules is 21% following administration of a 300 mg capsule dose, and 16% following administration of a 600 mg capsule dose. Estimated absolute bioavailability of cefdinir suspension is 25%. Absorption is reduced by approximately 15% when administered with a high fat meal.

Cefzon (TN) side effects and Toxicity

Information on cefdinir overdosage in humans is not available. In acute rodent toxicity studies, a single oral 5600-mg/kg dose produced no adverse effects. Toxic signs and symptoms following overdosage with other b-lactam antibiotics have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.

Cefzon (TN) Patient Information

Cefzon (TN) Organisms Affected

Enteric gram-negative rods