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Catapressan Brand names, Catapressan Analogs

Catapressan Brand Names Mixture

  • Combipres 0.1/15 Tab (Chlorthalidone + Clonidine Hydrochloride)

Catapressan Chemical_Formula


Catapressan RX_link

Catapressan fda sheet

Catapressan msds (material safety sheet)

Catapressan MSDS

Catapressan Synthesis Reference

Zeile et al.; U.S. Pat. 3,202,660(1965)

Catapressan Molecular Weight

230.093 g/mol

Catapressan Melting Point


Catapressan H2O Solubility


Catapressan State


Catapressan LogP


Catapressan Dosage Forms

Tablet; Patch

Catapressan Indication

For the treatment of hypertension and maybe used in prophylaxis of migraine or recurrent vascular headache; Menopausal flushing

Catapressan Pharmacology

Clonidine is an antihypertensive agent and an epidural agent for refractory cancer pain. Similar to guanabenz in mechanism of action, clonidine is used in the treatment of hypertension, opiate and nicotine withdrawal, vascular headaches, diabetic diarrhea, glaucoma, ulcerative colitis, Gilles de la Tourette's syndrome, menopause symptoms, severe pain in cancer patients refractory to opiate agonists, and neuropathic pain and in the diagnosis of pheochromocytoma.

Catapressan Absorption

Well absorbed following oral administration. Bioavailability following chronic administration is approximately 65%.

Catapressan side effects and Toxicity

Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

Catapressan Patient Information


Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of a potential sedative effect of clonidine. Patients should be cautioned against interruption of clonidine hydrochloride therapy without a physician's advice.

Epidural Injection

Patients should be instructed about the risks of rebound hypertension and warned not to discontinue clonidine except under the supervision of a physician. Patients should notify their physician immediately if clonidine administration is inadvertently interrupted for any reason. Patients who engage in potentially hazardous activities, such as operating machinery or driving, should be advised of the potential sedative and hypotensive effects of epidural clonidine. They should also be informed that sedative effects may be increased by CNS-depressing drugs such as alcohol and barbiturates, and that hypotensive effects may be increased by opiates.

Catapressan Organisms Affected

Humans and other mammals