Cardizem SR en es it fr

Cardizem SR Brand names, Cardizem SR Analogs

Cardizem SR Brand Names Mixture

  • No information avaliable

Cardizem SR Chemical_Formula


Cardizem SR RX_link

Cardizem SR fda sheet

Cardizem_SR FDA

Cardizem SR msds (material safety sheet)

Cardizem_SR MSDS

Cardizem SR Synthesis Reference

H. Kugita et al., U.S. Pat. 3,562,257 (1971)

Cardizem SR Molecular Weight

414.519 g/mol

Cardizem SR Melting Point


Cardizem SR H2O Solubility

465 mg/L

Cardizem SR State


Cardizem SR LogP


Cardizem SR Dosage Forms


Cardizem SR Indication

For the treatment of Hypertension

Cardizem SR Pharmacology

Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

Cardizem SR Absorption

Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect.

Cardizem SR side effects and Toxicity

LD50=740mg/kg (orally in mice)

Cardizem SR Patient Information


Take this medicine exactly as directed even if you feel well and do not notice any signs of chest pain.

Do not take more of this medicine and do not take it more often than your doctor ordered.

Do not miss any doses.

Diltiazem is a calcium channel blocking agents. For the calcium channel blocking agents, the following should be considered:

-Tell your doctor if you have ever had any unusual or allergic reaction to amlodipine, bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, or verapamil. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

-Calcium channel blocking agents have not been studied in pregnant women. However, studies in animals have shown that large doses of calcium channel blocking agents cause birth defects, prolonged pregnancy, poor bone development in the offspring, and stillbirth.

-Although bepridil, diltiazem, nifedipine, verapamil, and possibly other calcium channel blocking agents, pass into breast milk, they have not been reported to cause problems in nursing babies.

-Although there is no specific information comparing use of this medicine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

-Elderly people may be especially sensitive to the effects of calcium channel blocking agents. This may increase the chance of side effects during treatment. A lower starting dose may be required.

-The presence of other medical problems may affect the use of the calcium channel blocking agents. Make sure you tell your doctor if you have any other medical problems, especially

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Cardizem SR Organisms Affected

Humans and other mammals