Cardene SR

• Antiarrhythmic Agents
• Vasodilator Agents
• Antihypertensive Agents
• Dihydropyridines
• ATC:C08CA04

• Cardene
• Cardene SR
• Nicardipine HCl
• Nicardipino [Inn-Spanish]
• Nicardipinum [Inn-Latin]

• No information avaliable

C₂₆H₂₉N₃O₆

http://www.rxlist.com/cgi/generic/nicardipine.htm

Cardene_SR FDA

Cardene_SR MSDS

No information avaliable

479.525 g/mol

136-138 ^oC

2.2 mg/L

Solid

3.967

Capsule

Used for the management of patients with chronic stable angina and for the treatment of hypertension.

Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.

Oral LD₅₀ Rat = 184 mg/kg, Oral LD₅₀ Mouse = 322 mg/kg

No information avaliable

Humans and other mammals