Buspisal

• Anti-anxiety Agents
• Serotonin Agonists
• Anxiolytics sedatives and hypnotics
• ATC:N05BE01

• Ansial
• Ansiced
• Anxiron
• Axoren
• Bespar
• Buspar
• Buspimen
• Buspinol
• Buspirona [INN-Spanish]
• Buspirone HCL
• Buspironum [INN-Latin]
• Buspisal
• Censpar
• Lucelan
• Narol
• Travin

• No information avaliable

C₂₁H₃₁N₅O₂

http://www.rxlist.com/cgi/generic/buspir.htm

Buspisal FDA

Buspisal MSDS

U.S. Pat. 3,717,634 (1973)

385.503 g/mol

201.5-202.5^oC

21.4 mg/L

Solid

1.238

Tablet (5 mg, 10 mg)

For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression.

Buspirone is used in the treatment of generalized anxiety where it has advantages over other antianxiety drugs because it does not cause sedation (drowsiness) and does not cause tolerance or physical dependence. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. in vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT_1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models. Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.

Rapidly absorbed in man. Bioavailability is low and variable (approximately 5%) due to extensive first pass metabolism.

Oral, rat LD₅₀ = 136 mg/kg. Symptoms of overdose include dizziness, drowsiness, nausea or vomiting, severe stomach upset, and unusually small pupils.

Buspirone is used for the treatment of nervousness and anxiety. Optimum results are usually seen after three to four weeks of treatment. This medication may be taken with or without food. Inform your physican if you are pregnant or nursing. Buspirone may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking this medication. Do not take this medication with a monoamine oxidase inhibitor. Notify physician if you develop muscle spasms, uncontrolled twitching in the face and body, or uncontrolled tongue movements.

Humans and other mammals