Bricyn

• Adrenergic beta-Agonists
• Tocolytic Agents
• Bronchodilator Agents
• Sympathomimetic
• ATC:R03AC03
• ATC:R03CC03

• Brethaire
• Brethine
• Brican
• Bricanyl
• Bricar
• Bricaril
• Bricyn
• Terbutalin
• Terbutalina [Dcit]
• Terbutaline Sulfate
• Terbutalino [Inn-Spanish]
• Terbutalinum [Inn-Latin]

• No information avaliable

C₁₂H₁₉NO₃

http://www.rxlist.com/cgi/generic3/terbutaline.htm

Bricyn MSDS

K. Wetterlin, L. A. Svensson, Belg. pat. 704,932; eidem, U.S. pat. 3,937,838 (1968, 1976 both to Draco)

225.284 g/mol

119-122 ^oC

213 mg/mL

Solid

1.567

Metered-dose (aerosol); Powder; Tablets; IV injection; Subcutaneous injection

For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.

Terbutaline is a relatively selective beta2-adrenergic bronchodilator. The pharmacologic effects of beta adrenergic agonist drugs, including terbutaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

No information avaliable

Terbutaline Sulfate: Oral LD₅₀(rat) = 8.7 g/kg; Oral LD₅₀(mouse) = 205 mg/kg; Oral LD₅₀(dog) = 1.5 g/kg; IP LD₅₀(rat)= 220 mg/kg ; IP LD₅₀(mouse) = 130 mg/kg; Oral LD₅₀(rabbit) = >8 g/kg; IV LD₅₀(mouse) = 36 mg/kg; IV LD₅₀(dog) = 116 mg/kg; IV LD₅₀(rabbit) = 110 mg/kg

Humans and other mammals