Bretylium tolsylate en es it fr

Bretylium tolsylate Brand names, Bretylium tolsylate Analogs

Bretylium tolsylate Brand Names Mixture

  • No information avaliable

Bretylium tolsylate Chemical_Formula


Bretylium tolsylate RX_link

Bretylium tolsylate fda sheet

Bretylium tolsylate msds (material safety sheet)

Bretylium_tolsylate MSDS

Bretylium tolsylate Synthesis Reference

No information avaliable

Bretylium tolsylate Molecular Weight

243.163 g/mol

Bretylium tolsylate Melting Point

No information avaliable

Bretylium tolsylate H2O Solubility

Freely soluble

Bretylium tolsylate State


Bretylium tolsylate LogP

No information avaliable

Bretylium tolsylate Dosage Forms

Solution for injection (50mg/mL)

Bretylium tolsylate Indication

For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia, that have failed to respond to adequate doses of a first-line antiarrhythmic agent, such as lidocaine.

Bretylium tolsylate Pharmacology

Bretylium is a bromobenzyl quaternary ammonium compound which selectively accumulates in sympathetic ganglia and their postganglionic adrenergic neurons where it inhibits norepinephrine release by depressing adrenergic nerve terminal excitability. Bretylium also suppresses ventricular fibrillation and ventricular arrhythmias.

Bretylium tolsylate Absorption

No information avaliable

Bretylium tolsylate side effects and Toxicity

Oral, mouse: LD50 = 400 mg/kg. In the presence of life-threatening arrhythmias, underdosing with bretylium probably presents a greater risk to the patient than potential overdosage. However, one case of accidental overdose has been reported in which a rapidly injected intravenous bolus of 30 mg/kg was given instead of an intended 10 mg/kg dose during an episode of ventricular tachycardia. Marked hypertension resulted, followed by protracted refractory hypotension. The patient expired 18 hours later in asystole, complicated by renal failure and aspiration pneumonitis. Bretylium serum levels were 8000 ng/mL.

Bretylium tolsylate Patient Information

Bretylium tolsylate Organisms Affected

Humans and other mammals