Bretylium tolsylate
Bretylium tolsylate Brand names, Bretylium tolsylate Analogs
Bretylium tolsylate Brand Names Mixture
- No information avaliable
Bretylium tolsylate Chemical_Formula
C11H17BrN+
Bretylium tolsylate RX_link
http://www.rxlist.com/cgi/generic3/bretosy.htm
Bretylium tolsylate fda sheet
Bretylium tolsylate msds (material safety sheet)
Bretylium tolsylate Synthesis Reference
No information avaliable
Bretylium tolsylate Molecular Weight
243.163 g/mol
Bretylium tolsylate Melting Point
No information avaliable
Bretylium tolsylate H2O Solubility
Freely soluble
Bretylium tolsylate State
Solid
Bretylium tolsylate LogP
No information avaliable
Bretylium tolsylate Dosage Forms
Solution for injection (50mg/mL)
Bretylium tolsylate Indication
For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia, that have failed to respond to adequate doses of a first-line antiarrhythmic agent, such as lidocaine.
Bretylium tolsylate Pharmacology
Bretylium is a bromobenzyl quaternary ammonium compound which selectively accumulates in sympathetic ganglia and their postganglionic adrenergic neurons where it inhibits norepinephrine release by depressing adrenergic nerve terminal excitability. Bretylium also suppresses ventricular fibrillation and ventricular arrhythmias.
Bretylium tolsylate Absorption
No information avaliable
Bretylium tolsylate side effects and Toxicity
Oral, mouse: LD50 = 400 mg/kg. In the presence of life-threatening arrhythmias, underdosing with bretylium probably presents a greater risk to the patient than potential overdosage. However, one case of accidental overdose has been reported in which a rapidly injected intravenous bolus of 30 mg/kg was given instead of an intended 10 mg/kg dose during an episode of ventricular tachycardia. Marked hypertension resulted, followed by protracted refractory hypotension. The patient expired 18 hours later in asystole, complicated by renal failure and aspiration pneumonitis. Bretylium serum levels were 8000 ng/mL.
Bretylium tolsylate Patient Information
Bretylium tolsylate Organisms Affected
Humans and other mammals
