Bretylium Tosylate en es it fr

Bretylium Tosylate Brand names, Bretylium Tosylate Analogs

Bretylium Tosylate Brand Names Mixture

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Bretylium Tosylate Chemical_Formula


Bretylium Tosylate RX_link

Bretylium Tosylate fda sheet

Bretylium Tosylate msds (material safety sheet)

Bretylium_Tosylate MSDS

Bretylium Tosylate Synthesis Reference

No information avaliable

Bretylium Tosylate Molecular Weight

243.163 g/mol

Bretylium Tosylate Melting Point

No information avaliable

Bretylium Tosylate H2O Solubility

Freely soluble

Bretylium Tosylate State


Bretylium Tosylate LogP

No information avaliable

Bretylium Tosylate Dosage Forms

Solution for injection (50mg/mL)

Bretylium Tosylate Indication

For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia, that have failed to respond to adequate doses of a first-line antiarrhythmic agent, such as lidocaine.

Bretylium Tosylate Pharmacology

Bretylium is a bromobenzyl quaternary ammonium compound which selectively accumulates in sympathetic ganglia and their postganglionic adrenergic neurons where it inhibits norepinephrine release by depressing adrenergic nerve terminal excitability. Bretylium also suppresses ventricular fibrillation and ventricular arrhythmias.

Bretylium Tosylate Absorption

No information avaliable

Bretylium Tosylate side effects and Toxicity

Oral, mouse: LD50 = 400 mg/kg. In the presence of life-threatening arrhythmias, underdosing with bretylium probably presents a greater risk to the patient than potential overdosage. However, one case of accidental overdose has been reported in which a rapidly injected intravenous bolus of 30 mg/kg was given instead of an intended 10 mg/kg dose during an episode of ventricular tachycardia. Marked hypertension resulted, followed by protracted refractory hypotension. The patient expired 18 hours later in asystole, complicated by renal failure and aspiration pneumonitis. Bretylium serum levels were 8000 ng/mL.

Bretylium Tosylate Patient Information

Bretylium Tosylate Organisms Affected

Humans and other mammals