Biorphen

Biorphen Brand names, Biorphen Analogs

Biorphen Brand Names Mixture

No information avaliable

Biorphen Chemical_Formula

C₁₈H₂₃NO

Biorphen RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Biorphen fda sheet

Biorphen FDA

Biorphen msds (material safety sheet)

Biorphen MSDS

Biorphen Synthesis Reference

No information avaliable

Biorphen Molecular Weight

269.381 g/mol

Biorphen Melting Point

156-157 ^oC

Biorphen H₂O Solubility

Sparingly soluble in water

Biorphen State

Solid

Biorphen LogP

4.034

Biorphen Dosage Forms

Tablet (extended-release)

Biorphen Indication

Indicated for the treatment of Parkinson's disease.

Biorphen Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Biorphen Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Biorphen side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Biorphen Patient Information