Bicalutamide

• Antineoplastic Agents
• ATC:L02BB03

• Bicalutamide [Usan:Ban:Inn]
• Casodex

• No information avaliable

C₁₈H₁₄F₄N₂O₄S

http://www.rxlist.com/cgi/generic3/bicalutamide.htm

Bicalutamide FDA

Bicalutamide MSDS

No information avaliable

430.374 g/mol

191-193 ^oC

5 mg/L

Solid

3.049

Tablet

For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.

Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.

Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.

No information avaliable

Patients should be informed that therapy with CASODEX and the LHRH analogue should be initiated concomitantly, and that they should not interrupt or stop taking these medications without consulting their physician. Treatment with CASODEX should be started at the same time as treatment with an LHRH analogue.

Humans and other mammals