Balsalazide disodium
Balsalazide disodium Brand names, Balsalazide disodium Analogs
Balsalazide disodium Brand Names Mixture
- No information avaliable
Balsalazide disodium Chemical_Formula
C17H15N3O6
Balsalazide disodium RX_link
http://www.rxlist.com/cgi/generic2/balsalazide.htm
Balsalazide disodium fda sheet
Balsalazide disodium msds (material safety sheet)
Balsalazide disodium Synthesis Reference
No information avaliable
Balsalazide disodium Molecular Weight
357.318 g/mol
Balsalazide disodium Melting Point
No information avaliable
Balsalazide disodium H2O Solubility
Freely soluble as disodium salt
Balsalazide disodium State
Solid
Balsalazide disodium LogP
2.417
Balsalazide disodium Dosage Forms
Capsule (750 mg)
Balsalazide disodium Indication
For the treatment of mildly to moderately active ulcerative colitis.
Balsalazide disodium Pharmacology
Balsalazide is a prodrug that is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid), an anti inflammatory drug indicated for the treatment of mildly to moderately active ulcerative colitis. Balsalazide disodium is delivered intact to the colon where it is cleaved by bacterial azoreduction to release equimolar quantities of mesalamine, which is the therapeutically active portion of the molecule, and 4-aminobenzoyl-(beta)-alanine.
Balsalazide disodium Absorption
Low and variable, intact balsalazide is poorly absorbed systemically.
Balsalazide disodium side effects and Toxicity
A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
Balsalazide disodium Patient Information
No information avaliable
Balsalazide disodium Organisms Affected
Humans and other mammals
