Baclofen en es it fr

Baclofen Brand names, Baclofen Analogs

Baclofen Brand Names Mixture

  • No information avaliable

Baclofen Chemical_Formula

C10H12ClNO2

Baclofen RX_link

http://www.rxlist.com/cgi/generic/baclofen.htm

Baclofen fda sheet

Baclofen FDA

Baclofen msds (material safety sheet)

Baclofen Synthesis Reference

Neth. pat. Appl. 6,407,755; H. Keberle et al., U.S. pat. 3,471,548 (1965, 1969 both to Ciba)

Baclofen Molecular Weight

213.661 g/mol

Baclofen Melting Point

206-208 oC

Baclofen H2O Solubility

2090 mg/L

Baclofen State

Solid

Baclofen LogP

1.42

Baclofen Dosage Forms

Tablet; Intrathecal injection

Baclofen Indication

For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Baclofen Pharmacology

Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Baclofen Absorption

Rapidly and extensively absorbed

Baclofen side effects and Toxicity

LD50=45 mg/kg (male mice, IV); LD50=78 mg/kg (male rat, IV)

Baclofen Patient Information

Baclofen Organisms Affected

Humans and other mammals