Bacitracin
Bacitracin Brand names, Bacitracin Analogs
Bacitracin Brand Names Mixture
- No information avaliable
Bacitracin Chemical_Formula
C66H103N17O16S
Bacitracin RX_link
http://www.rxlist.com/cgi/generic3/bacit.htm
Bacitracin fda sheet
Bacitracin msds (material safety sheet)
Bacitracin Synthesis Reference
No information avaliable
Bacitracin Molecular Weight
1422.69 g/mol
Bacitracin Melting Point
221 - 225 oC
Bacitracin H2O Solubility
Freely soluble
Bacitracin State
Solid
Bacitracin LogP
-1.025
Bacitracin Dosage Forms
Drug premix; Ointment; Powder; Powder for solution
Bacitracin Indication
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections.
Bacitracin Pharmacology
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. As a polypeptide, toxic, and difficult to use chemical, Bacitracin doesn't work well orally, however is very effective topically. Bacitracin exerts pronounced antibacterial action in vitro against a variety of gram-positive and a few gram-negative organisms. However, among systemic diseases, only staphylococcal infections qualify for consideration of bacitracin therapy.
Bacitracin Absorption
Absorption of bacitracin following intramuscular injection is rapid and complete. Absorption from the gastrointestinal tract following oral administration is not appreciable. Absorption following topical application is negligible.
Bacitracin side effects and Toxicity
Oral, mouse: LD50 = >3750 mg/kg.
Bacitracin Patient Information
Bacitracin Organisms Affected
Enteric bacteria and other eubacteria
