Azelainic acid
Azelainic acid Brand names, Azelainic acid Analogs
Azelainic acid Brand Names Mixture
- No information avaliable
Azelainic acid Chemical_Formula
C9H16O4
Azelainic acid RX_link
http://www.rxlist.com/cgi/generic3/azelex.htm
Azelainic acid fda sheet
Azelainic acid msds (material safety sheet)
Azelainic acid Synthesis Reference
No information avaliable
Azelainic acid Molecular Weight
188.221 g/mol
Azelainic acid Melting Point
106.5 oC
Azelainic acid H2O Solubility
2400 mg/L (20°C)
Azelainic acid State
Solid
Azelainic acid LogP
1.646
Azelainic acid Dosage Forms
Cream (20%)
Azelainic acid Indication
For the topical treatment of mild-to-moderate inflammatory acne vulgaris.
Azelainic acid Pharmacology
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Azelainic acid Absorption
Approximately 4% of the topically applied azelaic acid is systemically absorbed.
Azelainic acid side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg.
Azelainic acid Patient Information
Azelainic acid Organisms Affected
Various aerobic and anaerobic microorganisms
