Avirax
Avirax Brand names, Avirax Analogs
Avirax Brand Names Mixture
- Zovirax Injection (Zovirax sodium)
Avirax Chemical_Formula
C8H11N5O3
Avirax RX_link
http://www.rxlist.com/cgi/generic/acyclo.htm
Avirax fda sheet
Avirax msds (material safety sheet)
Avirax Synthesis Reference
H. Matsumoto et al., Chem. Pharm. Bull. 35, 1153 (1988)
Avirax Molecular Weight
225.205 g/mol
Avirax Melting Point
256.5 - 257 oC
Avirax H2O Solubility
3.399 mg/L
Avirax State
Solid
Avirax LogP
-1.314
Avirax Dosage Forms
Intravenous infusion; Capsule; Tablet; Suspension; Topical cream; Topical ointment
Avirax Indication
For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox
Avirax Pharmacology
Acyclovir is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of acyclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV.
Avirax Absorption
Oral: bioavailability 10 to 20%
Avirax side effects and Toxicity
Acyclovir may cause nephrotoxicity (crystallization of acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of acyclovir therapy. However, there is no well-defined relationship between acyclovir concentrations in the blood and these adverse effects.
Avirax Patient Information
Avirax Organisms Affected
Human herpes virus
