Antizid

Category

Antizid




Useful info

Antizid Brand names, Antizid Analogs

Antizid Brand Names Mixture

  • No information avaliable

    • Antizid Chemical_Formula

    C12H21N5O2S2

    Antizid RX_link

    http://www.rxlist.com/cgi/generic/nizat.htm

    Antizid fda sheet

    Antizid FDA

    Antizid msds (material safety sheet)

    Antizid Synthesis Reference

    R. P. Pioch, U.S. Pat. 4,375,547 (1982)

    Antizid Molecular Weight

    331.46 g/mol

    Antizid Melting Point

    203 oC

    Antizid H2O Solubility

    10-33mg/mL

    Antizid State

    Solid

    Antizid LogP

    1.506

    Antizid Dosage Forms

    Capsule (150, 300 mg)

    Antizid Indication

    For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.

    Antizid Pharmacology

    Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.

    Antizid Absorption

    Rapid (bioavailability of nizatidine exceeds 70%)

    Antizid Toxicity

    Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.

    Antizid Patient Information

    Antizid Organisms Affected

    Humans and other mammals