Amphotericin_B
Category
Amphotericin_B Brand names, Amphotericin_B Analogs
Amphotericin_B Brand Names Mixture
No information avaliable
Amphotericin_B Chemical_Formula
C47H73NO17
Amphotericin_B RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Amphotericin_B fda sheet
Amphotericin_B msds (material safety sheet)
Amphotericin_B Synthesis Reference
No information avaliable
Amphotericin_B Molecular Weight
924.079 g/mol
Amphotericin_B Melting Point
170.0 oC
Amphotericin_B H2O Solubility
750 mg/L
Amphotericin_B State
Solid
Amphotericin_B LogP
0.947
Amphotericin_B Dosage Forms
Slow intravenous-infusion
Amphotericin_B Indication
Used to treat potentially life threatening fungal infections.
Amphotericin_B Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericin_B Absorption
Bioavailability is 100% for intravenous infusion.
Amphotericin_B Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Amphotericin_B Patient Information
No information avaliable
Amphotericin_B Organisms Affected
Various Fungus Species
