Amphotericin B
Amphotericin B Brand names, Amphotericin B Analogs
Amphotericin B Brand Names Mixture
- No information avaliable
Amphotericin B Chemical_Formula
C47H73NO17
Amphotericin B RX_link
http://www.rxlist.com/cgi/generic2/amphoter.htm
Amphotericin B fda sheet
Amphotericin B msds (material safety sheet)
Amphotericin B Synthesis Reference
No information avaliable
Amphotericin B Molecular Weight
924.079 g/mol
Amphotericin B Melting Point
170.0 oC
Amphotericin B H2O Solubility
750 mg/L
Amphotericin B State
Solid
Amphotericin B LogP
0.947
Amphotericin B Dosage Forms
Slow intravenous-infusion
Amphotericin B Indication
Used to treat potentially life threatening fungal infections.
Amphotericin B Pharmacology
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericin B Absorption
Bioavailability is 100% for intravenous infusion.
Amphotericin B side effects and Toxicity
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
Amphotericin B Patient Information
No information avaliable
Amphotericin B Organisms Affected
Various Fungus Species
