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Amitryptiline
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Useful info

Amitryptiline Brand names, Amitryptiline Analogs

Amitryptiline Brand Names Mixture

  • Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
  • Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
  • Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Amitryptiline Chemical_Formula

C20H23N

Amitryptiline RX_link

http://www.rxlist.com/cgi/generic/amitrip.htm

Amitryptiline fda sheet

Amitryptiline msds (material safety sheet)

Amitryptiline MSDS

Amitryptiline Synthesis Reference

Hoffsommer et al., J. Org. Chem. 27, 4134 (1962)

Amitryptiline Molecular Weight

277.403 g/mol

Amitryptiline Melting Point

196-197 oC

Amitryptiline H2O Solubility

9.7 mg/mL

Amitryptiline State

Solid

Amitryptiline LogP

4.612

Amitryptiline Dosage Forms

Syrup; Tablet (10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg)

Amitryptiline Indication

For the treatment of anxiety, bipolar disorders, and depression.

Amitryptiline Pharmacology

Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).

Amitryptiline Absorption

Rapidly and well absorbed following oral administration (bioavailability is 30-60% due to first pass metabolism).

Amitryptiline side effects and Toxicity

LD50=350 mg/kg (in mice). Symptoms of overdose include abnormally low blood pressure, confusion, convulsions, dilated pupils and other eye problems, disturbed concentration, drowsiness, hallucinations, impaired heart function, rapid or irregular heartbeat, reduced body temperature, stupor, and unresponsiveness or coma.

Amitryptiline Patient Information

While on therapy with amitriptyline HCl, patients should be advised as to the possible impairment of mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

Amitryptiline Organisms Affected

Humans and other mammals