Aminoglutethimide
Aminoglutethimide Brand names, Aminoglutethimide Analogs
Aminoglutethimide Brand Names Mixture
- No information avaliable
Aminoglutethimide Chemical_Formula
C13H16N2O2
Aminoglutethimide RX_link
http://www.rxlist.com/cgi/generic3/cytadren.htm
Aminoglutethimide fda sheet
Aminoglutethimide msds (material safety sheet)
Aminoglutethimide Synthesis Reference
Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)
Aminoglutethimide Molecular Weight
232.278 g/mol
Aminoglutethimide Melting Point
149-150 oC
Aminoglutethimide H2O Solubility
Practically insoluble in water
Aminoglutethimide State
Solid
Aminoglutethimide LogP
2.029
Aminoglutethimide Dosage Forms
Tablet (250 mg)
Aminoglutethimide Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Aminoglutethimide Pharmacology
Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.
Aminoglutethimide Absorption
Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.
Aminoglutethimide side effects and Toxicity
Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
Aminoglutethimide Patient Information
Aminoglutethimide Organisms Affected
Humans and other mammals
