PharmacyCodes



Aminodarone en es it fr

Aminodarone Brand names, Aminodarone Analogs

Aminodarone Brand Names Mixture

  • No information avaliable

Aminodarone Chemical_Formula

C25H29I2NO3

Aminodarone RX_link

http://www.rxlist.com/cgi/generic/amiodarone.htm

Aminodarone fda sheet

Aminodarone FDA

Aminodarone msds (material safety sheet)

Aminodarone MSDS

Aminodarone Synthesis Reference

No information avaliable

Aminodarone Molecular Weight

645.312 g/mol

Aminodarone Melting Point

No information avaliable

Aminodarone H2O Solubility

Low

Aminodarone State

Solid

Aminodarone LogP

7.706

Aminodarone Dosage Forms

Liquid; Solution; Tablet (200 mg and 400 mg)

Aminodarone Indication

Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.

Aminodarone Pharmacology

Amiodarone belongs to a class of drugs called Vaughan-Williams Class III antiarrhythmic agents. It is used in the treatment of a wide range of cardiac tachyarhthmias, including both ventricular and supraventricular (atrial) arrhythmias. After intravenous administration in man, amiodarone relaxes vascular smooth muscle, reduces peripheral vascular resistance (afterload), and slightly increases cardiac index. Amiodarone prolongs phase 3 of the cardiac action potential. It has numerous other effects however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. Amiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects.

Aminodarone Absorption

Slow and variable (about 20 to 55% of an oral dose is absorbed).

Aminodarone side effects and Toxicity

Intravenous, mouse: LD50 = 178 mg/kg. Some side effects have a significant mortality rate: specifically, hepatitis, exacerbation of asthma and congestive failure, and pneumonitis.

Aminodarone Patient Information

No information avaliable

Aminodarone Organisms Affected

Humans and other mammals