Amikar
Amikar Brand names, Amikar Analogs
Amikar Brand Names Mixture
- No information avaliable
Amikar Chemical_Formula
C6H13NO2
Amikar RX_link
http://www.rxlist.com/cgi/generic/amicarpre.htm
Amikar fda sheet
Amikar msds (material safety sheet)
Amikar Synthesis Reference
No information avaliable
Amikar Molecular Weight
131.173 g/mol
Amikar Melting Point
205 oC
Amikar H2O Solubility
5.05E+005 mg/L
Amikar State
Solid
Amikar LogP
0.306
Amikar Dosage Forms
Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)
Amikar Indication
For use in the treatment of excessive postoperative bleeding.
Amikar Pharmacology
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.
Amikar Absorption
Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Amikar side effects and Toxicity
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Amikar Patient Information
Amikar Organisms Affected
Humans and other mammals
