Amarin

Category

Amarin




Useful info

Amarin Brand names, Amarin Analogs

Amarin Brand Names Mixture

  • No information avaliable

    • Amarin Chemical_Formula

    C16H14F3N3O2S

    Amarin RX_link

    http://www.rxlist.com/cgi/generic/lansop.htm

    Amarin fda sheet

    Amarin FDA

    Amarin msds (material safety sheet)

    Amarin Synthesis Reference

    A. Nohara, Y. Marki, U.S. Pat. 4,628,098 (1986)

    Amarin Molecular Weight

    369.363 g/mol

    Amarin Melting Point

    178-182 oC

    Amarin H2O Solubility

    0.97 mg/L

    Amarin State

    Solid

    Amarin LogP

    1.733

    Amarin Dosage Forms

    Enteric coated capsules

    Amarin Indication

    For treatment of Acid-reflux disorders (GERD), peptic Ulcer Disease, duodenal ulcers, esophagitis, and Zollinger-Ellison syndrome

    Amarin Pharmacology

    Lansoprazole, an acid proton-pump inhibitor similar to omeprazole, is used as an untiulcer drug in the treatment and maintenance of healing of duodenal or gastric ulcers, erosive and reflux esophagitis, NSAID-induced ulcer, Zollinger-Ellison syndrome, and Barrett's esophagus. Lansoprozole is active against Helicobacter pylori. The plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Thus, the plasma elimination half-life is less than two hours, while the acid inhibitory effect lasts more than 24 hours.

    Amarin Absorption

    The absorption of lansoprazole is rapid, with mean Cmax occurring approximately 1.7 hours after oral dosing, and relatively complete with absolute bioavailability over 80%.

    Amarin Toxicity

    Symptoms of overdose include abdominal pain, nausea and diarrhea.

    Amarin Patient Information

    Lansoprazole is used short-term (4-8 weeks) to treat duodenal ulcer and erosive esophagitis. It may used long term to treat Zollinger-Ellison syndrome, a problem with too much acid being secreted. Lansoprazole capsules should be taken before eating. The capsules are delayed release' meaning they work over time. The capsules should be swallowed whole and not crushed, opened or chewed. If you are taking theophylline, you may need your dosage checked when you start and stop lansoprazole to ensure your dose is effective. If you are taking sucralfate, it should be taken 30 minutes after taking lansoprazole. The most common side effects reported were diarrhea, nausea and abdominal pain. These occurred in fewer than 5% of patients. If your symptoms return after completing your course of therapy, talk to your physician for further evaluation.

    Amarin Organisms Affected

    Humans and other mammals