Alendronate
Alendronate Brand names, Alendronate Analogs
Alendronate Brand Names Mixture
- No information avaliable
Alendronate Chemical_Formula
C4H13NO7P2
Alendronate RX_link
http://www.rxlist.com/cgi/generic/alendron.htm
Alendronate fda sheet
Alendronate msds (material safety sheet)
Alendronate Synthesis Reference
M. I. Kabachnik et al., Bull. Acad. Sci. USSR,.27, 374 (1978)
Alendronate Molecular Weight
249.096 g/mol
Alendronate Melting Point
233 - 235 oC
Alendronate H2O Solubility
1mg/L
Alendronate State
Solid
Alendronate LogP
-3.198
Alendronate Dosage Forms
Tablets (6.53, 13.05, 45.68, 52.21 or 91.37 mg of alendronate monosodium salt trihydrate)
Alendronate Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Alendronate Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Alendronate Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Alendronate side effects and Toxicity
Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of "pill esophagitis."
Alendronate Patient Information
Alendronate Organisms Affected
Humans and other mammals
