Adapalene
Adapalene Brand names, Adapalene Analogs
Adapalene Brand Names Mixture
- No information avaliable
Adapalene Chemical_Formula
C28H28O3
Adapalene RX_link
http://www.rxlist.com/cgi/generic3/adapalene.htm
Adapalene fda sheet
Adapalene msds (material safety sheet)
Adapalene Synthesis Reference
No information avaliable
Adapalene Molecular Weight
412.52 g/mol
Adapalene Melting Point
No information avaliable
Adapalene H2O Solubility
Practically Insoluble
Adapalene State
Solid
Adapalene LogP
7.884
Adapalene Dosage Forms
Gel (0.1%); Solution; Pledglets; Cream
Adapalene Indication
For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.
Adapalene Pharmacology
Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Adapalene Absorption
Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials
Adapalene side effects and Toxicity
The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
Adapalene Patient Information
Adapalene Organisms Affected
Humans and other mammals
