Acuitel
Acuitel Brand names, Acuitel Analogs
Acuitel Brand Names Mixture
- No information avaliable
Acuitel Chemical_Formula
C25H30N2O5
Acuitel RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Acuitel fda sheet
Acuitel msds (material safety sheet)
Acuitel Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Acuitel Molecular Weight
438.516 g/mol
Acuitel Melting Point
120-130oC
Acuitel H2O Solubility
1 mg/L
Acuitel State
Solid
Acuitel LogP
3.384
Acuitel Dosage Forms
Tablets
Acuitel Indication
For the treatment of hypertension and chronic heart failure.
Acuitel Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Acuitel Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Acuitel side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Acuitel Patient Information
Acuitel Organisms Affected
Humans and other mammals
