Acidum_meclofenamicum_[INN-Latin]

Category

Acidum_meclofenamicum_[INN-Latin]




Useful info

Acidum_meclofenamicum_[INN-Latin] Brand names, Acidum_meclofenamicum_[INN-Latin] Analogs

Acidum_meclofenamicum_[INN-Latin] Brand Names Mixture

  • No information avaliable

    • Acidum_meclofenamicum_[INN-Latin] Chemical_Formula

    C5H4N4S

    Acidum_meclofenamicum_[INN-Latin] RX_link

    http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

    Acidum_meclofenamicum_[INN-Latin] fda sheet

    Acidum_meclofenamicum_[INN-Latin] FDA

    Acidum_meclofenamicum_[INN-Latin] msds (material safety sheet)

    Acidum_meclofenamicum_[INN-Latin] MSDS

    Acidum_meclofenamicum_[INN-Latin] Synthesis Reference

    No information avaliable

    Acidum_meclofenamicum_[INN-Latin] Molecular Weight

    152.178 g/mol

    Acidum_meclofenamicum_[INN-Latin] Melting Point

    313 oC

    Acidum_meclofenamicum_[INN-Latin] H2O Solubility

    6.85 mg/mL

    Acidum_meclofenamicum_[INN-Latin] State

    Solid

    Acidum_meclofenamicum_[INN-Latin] LogP

    0.335

    Acidum_meclofenamicum_[INN-Latin] Dosage Forms

    Tablet (50-mg, scored) for oral administration

    Acidum_meclofenamicum_[INN-Latin] Indication

    For remission induction and maintenance therapy of acute lymphatic leukemia.

    Acidum_meclofenamicum_[INN-Latin] Pharmacology

    Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

    Acidum_meclofenamicum_[INN-Latin] Absorption

    Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

    Acidum_meclofenamicum_[INN-Latin] Toxicity

    Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

    Acidum_meclofenamicum_[INN-Latin] Patient Information

    No information avaliable

    Acidum_meclofenamicum_[INN-Latin] Organisms Affected

    Humans and other mammals