Acide_meclofenamique_[INN-French]

Category

Acide_meclofenamique_[INN-French]




Useful info

Acide_meclofenamique_[INN-French] Brand names, Acide_meclofenamique_[INN-French] Analogs

Acide_meclofenamique_[INN-French] Brand Names Mixture

  • No information avaliable

    • Acide_meclofenamique_[INN-French] Chemical_Formula

    C5H4N4S

    Acide_meclofenamique_[INN-French] RX_link

    http://www.rxlist.com/cgi/generic2/mercaptopurine.htm

    Acide_meclofenamique_[INN-French] fda sheet

    Acide_meclofenamique_[INN-French] FDA

    Acide_meclofenamique_[INN-French] msds (material safety sheet)

    Acide_meclofenamique_[INN-French] MSDS

    Acide_meclofenamique_[INN-French] Synthesis Reference

    No information avaliable

    Acide_meclofenamique_[INN-French] Molecular Weight

    152.178 g/mol

    Acide_meclofenamique_[INN-French] Melting Point

    313 oC

    Acide_meclofenamique_[INN-French] H2O Solubility

    6.85 mg/mL

    Acide_meclofenamique_[INN-French] State

    Solid

    Acide_meclofenamique_[INN-French] LogP

    0.335

    Acide_meclofenamique_[INN-French] Dosage Forms

    Tablet (50-mg, scored) for oral administration

    Acide_meclofenamique_[INN-French] Indication

    For remission induction and maintenance therapy of acute lymphatic leukemia.

    Acide_meclofenamique_[INN-French] Pharmacology

    Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.

    Acide_meclofenamique_[INN-French] Absorption

    Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.

    Acide_meclofenamique_[INN-French] Toxicity

    Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.

    Acide_meclofenamique_[INN-French] Patient Information

    No information avaliable

    Acide_meclofenamique_[INN-French] Organisms Affected

    Humans and other mammals