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Acepramine Brand names, Acepramine Analogs

Acepramine Brand Names Mixture

  • No information avaliable

Acepramine Chemical_Formula

C6H13NO2

Acepramine RX_link

http://www.rxlist.com/cgi/generic/amicarpre.htm

Acepramine fda sheet

Acepramine FDA

Acepramine msds (material safety sheet)

Acepramine MSDS

Acepramine Synthesis Reference

No information avaliable

Acepramine Molecular Weight

131.173 g/mol

Acepramine Melting Point

205 oC

Acepramine H2O Solubility

5.05E+005 mg/L

Acepramine State

Solid

Acepramine LogP

0.306

Acepramine Dosage Forms

Solution for injection (containing 250 mg/mL of aminocaproic acid) and tablets (500, 1000mg)

Acepramine Indication

For use in the treatment of excessive postoperative bleeding.

Acepramine Pharmacology

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

Acepramine Absorption

Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).

Acepramine side effects and Toxicity

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

Acepramine Patient Information

Acepramine Organisms Affected

Humans and other mammals