Accuprin
Accuprin Brand names, Accuprin Analogs
Accuprin Brand Names Mixture
- No information avaliable
Accuprin Chemical_Formula
C25H30N2O5
Accuprin RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Accuprin fda sheet
Accuprin msds (material safety sheet)
Accuprin Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Accuprin Molecular Weight
438.516 g/mol
Accuprin Melting Point
120-130oC
Accuprin H2O Solubility
1 mg/L
Accuprin State
Solid
Accuprin LogP
3.384
Accuprin Dosage Forms
Tablets
Accuprin Indication
For the treatment of hypertension and chronic heart failure.
Accuprin Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Accuprin Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Accuprin side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Accuprin Patient Information
Accuprin Organisms Affected
Humans and other mammals
