ASTA

Category

ASTA




Useful info

ASTA Brand names, ASTA Analogs

ASTA Brand Names Mixture

  • No information avaliable

    • ASTA Chemical_Formula

    C7H15Cl2N2O2P

    ASTA RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    ASTA fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    ASTA msds (material safety sheet)

    ASTA MSDS

    ASTA Synthesis Reference

    No information avaliable

    ASTA Molecular Weight

    261.085 g/mol

    ASTA Melting Point

    39-41 oC

    ASTA H2O Solubility

    3780 mg/L

    ASTA State

    Solid

    ASTA LogP

    -0.01

    ASTA Dosage Forms

    Powder for constitution and administration by intravenous infusion

    ASTA Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    ASTA Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    ASTA Absorption

    No information avaliable

    ASTA Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    ASTA Patient Information

    No information avaliable

    ASTA Organisms Affected

    Humans and other mammals