2'-Dexoycoformycin
Category
2'-Dexoycoformycin Brand names, 2'-Dexoycoformycin Analogs
2'-Dexoycoformycin Brand Names Mixture
2'-Dexoycoformycin Chemical_Formula
C11H16N4O4
2'-Dexoycoformycin RX_link
No information avaliable
2'-Dexoycoformycin fda sheet
2'-Dexoycoformycin msds (material safety sheet)
2'-Dexoycoformycin Synthesis Reference
Showalter, HD et al., J. Med. Chem. 26:1478 (1983)
2'-Dexoycoformycin Molecular Weight
268.269 g/mol
2'-Dexoycoformycin Melting Point
220 oC
2'-Dexoycoformycin H2O Solubility
30 mg/mL
2'-Dexoycoformycin State
Solid
2'-Dexoycoformycin LogP
-1.58
2'-Dexoycoformycin Dosage Forms
Powder for solution
2'-Dexoycoformycin Indication
For the treatment of hairy cell leukaemia refractory to alpha interferon.
2'-Dexoycoformycin Pharmacology
Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guanine. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
2'-Dexoycoformycin Absorption
Not absorbed orally, crosses blood brain barrier.
2'-Dexoycoformycin Toxicity
LD50=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
2'-Dexoycoformycin Patient Information
2'-Dexoycoformycin Organisms Affected
Humans and other mammals
